HIGHLIGHTED TOPIC Upper Airway Control and Function: Implications for Sleep-Disordered Breathing The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway
نویسندگان
چکیده
Robert L. Owens, Bradley A. Edwards, Scott A. Sands, James P. Butler, Danny J. Eckert, David P. White, Atul Malhotra, and Andrew Wellman Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Neuroscience Research Australia (NeuRA) and the School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia; and Pulmonary and Critical Care Division, University of California-San Diego, La Jolla, California
منابع مشابه
A Numerical Simulation of Inspiratory Airflow in Human Airways during Exercise at Sea Level and at High Altitude
At high altitudes, the air pressure is much lower than it is at sea level and contains fewer oxygen molecules and less oxygen is taken in at each breath. This requires deeper and rapid breathing to get the same amount of oxygen into the blood stream compared to breathing in air at sea level. Exercises increase the oxygen demand and make breathing more difficult at high altitude. In this study, ...
متن کاملThe effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse.
Obese leptin-deficient (ob/ob) mice demonstrate defects in upper airway structural and neuromuscular control. We hypothesized that these defects predispose to upper airway obstruction during sleep, and improve with leptin administration. High-fidelity polysomnographic recordings were conducted to characterize sleep and breathing patterns in conscious, unrestrained ob/ob mice (23 wk, 67.2 ± 4.1 ...
متن کاملSLEEP DISORDERED BREATHING INTRODUCTION IN OBSTRUCTIVE SLEEP APNEA (OSA), REPETITIVE COL- LAPSE OF THE UPPER AIRWAY DURING SLEEP RESULTS IN MULTIPLE EPISODES OF HYPOXEMIA AND subsequent repetitive arousals
IN OBSTRUCTIVE SLEEP APNEA (OSA), REPETITIVE COLLAPSE OF THE UPPER AIRWAY DURING SLEEP RESULTS IN MULTIPLE EPISODES OF HYPOXEMIA AND subsequent repetitive arousals that fragment sleep. These events and the associated autonomic and neurohumoral disturbances are considered to lead to the many symptoms and signs of OSA and contribute to the long-term morbidity.1,2 The repetitive arousals are a dom...
متن کاملHIGHLIGHTED TOPIC Upper Airway Control and Function: Implications for Sleep-Disordered Breathing Biomechanical properties of the human upper airway and their effect on its behavior during breathing and in obstructive sleep apnea
Bilston LE, Gandevia SC. Biomechanical properties of the human upper airway and their effect on its behavior during breathing and in obstructive sleep apnea. J Appl Physiol 116: 314 –324, 2014. First published July 3, 2013; doi:10.1152/japplphysiol.00539.2013.—The upper airway is a complex, multifunctional, dynamic neuromechanical system. Its patency during breathing requires moment-to-moment c...
متن کاملEffects of oral narcotics on sleep-disordered breathing in healthy adults.
Alcohol and benzodiazepines may increase sleep-disordered breathing by decreasing activity of pharyngeal dilating muscles, favoring the development of obstructive apneas and hypopneas. Narcotics cause greater depression of wakeful respiration than the previously mentioned drugs; however, the influence of narcotics on the upper airway and breathing during sleep has not been studied. We, therefor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014